| pCBRG-ISRE |
| Cat.No.: | RQV20016 |
| Description: | pISRE-Luc is designed for monitoring the induction of interferon stimulated response element.The JAK (Janus kinase) /STAT (Signal Transducer and Activator of Transcription) pathway is activated by various cytokines and growth factors and plays a critical role in cell growth, hematopoiesis, and immune response. In mammals, there are four JAKs (JAK1, JAK2, JAK3 and TYK2) and seven STAT proteins. Binding of Interferon alpha (IFNα) to its receptor leads to the activation of JAK1 and TYK2, which in turn phosphorylate and activate STAT1 and STAT2. The phosphorylated STAT1 and 2 form a heterodimer and bind to IRF9/p48, forming a protein complex known as ISGF3. This complex translocates to the nucleus and binds to the ISRE (Interferon Stimulated Response Element) in the promoter region thereby promoting transcription of interferon-inducible genes. |
| Plasmid profile: |  |
| Unit Size: | 1-4μg |
| Pathway (Activitor): | Jak/STAT-mediated signal transduction pathway (IFNa) |
| Pathway profile: |  |
| Full Name: | Signal transducer and activator of transcription 1&2 |
| Cis response element: | ISRE(Interferon Stimulated Response Element) |
| Shelf Life: | One year from date of receipt under proper storage conditions. |
| Storage: | -20°C |
| Mode of transportation: | Ice bag transport |
| Matters needing attention: | For your health, please wear lab clothes and disposable gloves. |
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