Drug Resistant

    Drug resistance generally refers to the decrease or even disappearance of the sensitivity of the drug to the pathogen after repeated contact with the drug, resulting in a decrease or ineffectiveness of the drug against the pathogen. The emergence of drug resistance has prevented many drugs from exerting their proper therapeutic effects, leading to the failure of drug efficacy. The mechanism of drug resistance in tumor cells is very complicated, and the establishment of multidrug resistant cell lines in vitro is an important means to study multidrug resistance of tumors. Drug-resistant cell lines generally use in vitro low-concentration gradient combined with high-dose intermittent impact method to induce tumor cells to develop resistance to specific drugs, thereby establishing corresponding drug-resistant cell lines.