Detailed introduction

Panel-Ref® gDNA All-in-One Reference Standard Plus
Cat No.	RQP90043
Format	Genomic DNA
Description	Pan-tumor large panel standard Panel-Ref® gDNA All-in-One Reference Standard Plus;, which is a reference material, quality control material, and standard material designed for large panel genes, can be used for QC verification of the detection process. Including accuracy, repeatability, detection limit, etc.
Validate genes	1000x WES: >5000
	425 gene-panel: >200
	528 gene-panel: >250
	ddPCR: >50
Verification site	1000x WES: >7000
	425 gene-panel: >300
	528 gene-panel: >450
	ddPCR: 82
MSI	MSI-H:NGS 92.31%，PCR 100%MSI；
TMB	415.0 mutations/Mb
MMR	MLH1 p.L323M exon 11 missense mutation;
	MLH1 p.S252* exon 9 nonsense mutation;
	MLH1 p.K618Del non-frameshift deletion mutation in exon 16;
	MSH6 p.Y1066* nonsense mutation in exon 5;
	PMS2 p.D414Tfs*34 exon 11 frameshift mutation;
	etc.
425 gene-Panel、528 gene-Panel、DdPCR and WES 1000X
%AF range	1-100%
Concentration	40 ng/uL±10%
Data	lick to dowload
	1000x WES
	425 gene-panel（Cooperators' Panel）
	528 gene-panel（Cobioers' Panel）
	DdPCR
			Chr position（GRCh37）
Gene	AA Change	CDS Change		Method
Gene	AA Change	CDS Change		ddPCR	528-GenePanel	425-GenePanel	1000xWES
EGFR	G719A	c.2156G>C	chr7:55241708	5.78%	4.68%	4.85%	6.00%
EGFR	C797S	c.2390G>C	chr7:55249092	4.01%	4.26%	3.80%	N/A
EGFR	E746_A750del	c.2235_2249del15 GGAATTAAGAGAAGC>-	chr7:55242465_55242479	1.85%	1.75%	0.63%	N/A
EGFR	S768I	c.2303G>T	chr7:55249005	2.68%	2.55%	3.05%	N/A
ERBB2	A775_G776insYVMA	c.2324_2325ins12ATACGTGATGGC	chr17:37880995_37880996	2.55%	2.35%	1.72%	N/A
MET	c.3082+1G>T	c.3082+1G>T	chr7:116412044	2.71%	2.57%	1.98%	N/A
ROS1	CD74-ROS1	CD74-ROS1		2.08%	N/A	N/A	N/A
PDGFRA	D842V	c.2525A>T	chr4:55152093	1.58%	2.52%	2.85%	N/A
KRAS	Q61H	c.183A>T	chr12:25380275	4.57%	4.87%	4.43%	3.96%
KRAS	A146T	c.436G>A	chr12:25378562	2.59%	3.07%	2.69%	3.25%
C-KIT	D816V	c.2447A>T	chr4:55599321	2.20%	3.78%	4.15%	2.99%
NRAS	G12D	c.35G>A	chr1:115258747	6.54%	5.79%	6.33%	7.12%
FLT3	I836DEL	c.2508_2510delCAT	chr13:28592637_28592639	4.78%	N/A	3.71%	3.62%
IDH2	R172K	c.515G>A	chr15:90631838	4.65%	3.35%	3.74%	4.33%
FGFR3	S249C	c.746C>G	chr4:1803568	3.09%	2.56%	2.47%	N/A
AKT1	E17K	c.49G>A	chr14:105246551	4.64%	3.21%	5.50%	4.48%
EGFR	T790M	c.2369C>T	chr7:55249071	3.00%	3.79%	2.65%	N/A
EGFR	L858R	c.2573T>G	chr7:55259515	5.07%	1.71%	2.83%	4.33%
IDH2	R140Q	c.419G>A	chr15:90631934	2.65%	3.44%	4.27%	N/A
BTK	C481S	c.1442G>C	chrX:100611164	3.16%	2.20%	2.70%	3.50%
KRAS	G13D	c.38G>A	chr12:25398281	8.66%	6.86%	8.33%	6.73%
BRCA2	I2675FS	c.8021dup	chr13:32937354	11.87%	10.37%	11.16%	8.41%
BRAF	V600E	c.1799T>A	chr7:140453136	43.55%	42.65%	43.96%	40.79%
PIK3CA	H1047R	c.3140A>G	chr3:178952085	31.74%	28.96%	33.14%	33.14%
NRAS	Q61K	c.181C>A	chr1:115256530	12.81%	13.92%	12.52%	14.76%
IDH1	R132C	c.394C>T	chr2:209113113	14.15%	13.02%	15.61%	11.86%
BRCA1	D435Y	c.1303G>T	chr17:41246245	28.77%	25.72%	24.03%	31.21%
BRCA2	N1784fs	c.5351delA	chr13:32913837	29.28%	28.75%	24.34%	N/A
CTNNB1	S45del	c.133_135delTCT	chr3:41266134_41266136	8.51%	6.48%	7.28%	8.11%
FANCA	345Vfs*63	c.1034_1035del	chr16:89858927_89858928	24.50%	27.05%	19.18%	N/A
GATA2	G200Vfs	c.599del	chr3:128204842	4.78%	N/A	5.05%	5.61%
BCORL1	P1681Qfs	c.5042del	chrX:129190011	48.11%	47.70%	N/A	N/A
RUNX1	M267I	c.801G>A	chr21:36206711	8.59%	7.73%	7.44%	7.59%
APC	K1454E	c.4360A>G	chr5:112175651	26.08%	26.32%	26.37%	N/A
IDH2	G190D	c.569G>A	chr15:90631700	26.98%	26.48%	27.18%	30.77%
EZH2	E169K	c.505G>A	chr7:148525952	21.57%	23.26%	N/A	16.20%
FANCA	P615Hfs	c.1844del	chr16:89842206	7.92%	7.75%	6.73%	7.49%
KMT2A	P773Rfs*8	c.2318del	chr11:118344186	28.95%	27.03%	26.61%	N/A
MSH6	Y1066*	c.3198_3199del	chr2:48030582	4.86%	4.66%	5.09%	3.80%
NF1	N2341Tfs*5	c.7022del	chr17:29667620	26.79%	25.38%	22.94%	19.50%
ARID1A	P1115Qfs*46	c.3344del	chr1:27097751	27.74%	26.36%	19.94%	28.21%
PPP2R1A	R183P	c.548G>C	chr19:52715983	8.03%	4.77%	8.33%	6.27%
MLH3	K585Rfs	c.1754_1755del	chr14:75514604	26.80%	N/A	25.15%	N/A
NF1	Y628Tfs*3	c.1882del	chr17:29552144	27.12%	23.94%	26.42%	24.08%
ARID1A	D1850Tfs*33	c.5548del	chr1:27105931	26.88%	26.79%	24.78%	N/A
MLH1	S252*	c.755C>A	chr3:37056000	17.49%	16.73%	12.92%	14.79%
MSH6	T1085Hfs*8	c.3261dup	chr2:48030639	5.62%	N/A	N/A	N/A
TSC2	Y602H	c.1804T>C	chr16:2120544	27.03%	26.11%	26.80%	24.92%
TSC2	V805I	c.2413G>A	chr16:2124258	27.49%	25.43%	25.27%	22.11%
TET1	N1611Tfs*13	c.4832del	chr10:70441157	27.79%	22.83%	N/A	N/A
BCOR	R1209Tfs*7	c.3624dup	chrX:39923086	11.45%	12.06%	N/A	10.00%
FGFR2	P583L	c.1748C>T	chr10:123256164	7.74%	8.42%	8.69%	12.10%
CDH1	H121Tfs*94	c.360del	chr16:68835766	9.17%	7.05%	9.27%	11.01%
NF1	P678Rfs*10	c.2033del	chr17:29553478	9.24%	N/A	8.19%	N/A
MSH3	K383Rfs*32	c.1148del	chr5:79970915	72.42%	N/A	N/A	N/A
ABL1	Y257C	c.770A>G	chr9:133738370	7.17%	6.64%	N/A	5.72%
IDH1	S261L	c.782C>T	chr2:209106786	7.29%	9.55%	8.13%	9.46%
ABL1	F747I	c.2239T>A	chr9:133759916	4.03%	4.54%	N/A	3.35%
AR	T306I	c.917C>T	chrX:66765905	36.53%	37.38%	35.04%	37.99%
KMT2A	D877Pfs*8	c.2629_2630del	chr11:118344494	26.95%	27.11%	23.73%	N/A
ATRX	T1529del	c.4586_4588del	chrX:76891517	10.43%	11.71%	10.54%	11.58%
CDKN2A	G23fs	c.68dup	chr9:21974758	12.77%	N/A	8.85%	10.99%
CDKN2A	E33fs	c.97del	chr9:21994234	12.53%	14.05%	12.07%	10.09%
GATA3	P127Rfs*68	c.380del	chr10:8100403	3.77%	N/A	3.06%	5.61%
MLH1	K618del	c.1852_1854del	chr3:37089123	4.75%	N/A	3.48%	N/A
ERCC5	c.2533+2T>C	c.2533+2T>C	chr13:103519197	8.01%	8.62%	7.10%	8.76%
EP300	K292Rfs*25	c.875del	chr22:41522009	26.98%	25.85%	22.87%	27.24%
CREBBP	c.1824-2A>G	c.1824-2A>G	chr16:3828820	26.72%	28.95%	30.92%	43.48%
B2M	R117*	c.349C>T	chr15:45008529	27.75%	25.07%	24.19%	26.47%
PMS2	D414Tfs*3	c.1239del	chr7:6027157	22.04%	16.40%	19.30%	N/A
SMARCA4	Y120Sfs*9	c.363dup	chr19:11096868	8.66%	8.53%	8.81%	12.72%
EP300	M1470Cfs*26	c.4408del	chr22:41566525	36.20%	35.37%	32.22%	N/A
EP300	N1700Tfs*9	c.5099del	chr22:41572810	8.43%	8.18%	9.43%	7.41%
KMT2D	G3465*	c.10393G>T	chr12:49428412	27.42%	23.06%	N/A	23.05%
KMT2D	P2550Lfs*33	c.7649del	chr12:49428412	26.82%	26.44%	N/A	26.92%
MEF2B	V316Sfs*6	c.944dup	chr19:19256768	26.33%	N/A	17.49%	N/A
KMT2D	G1960Afs*87	c.5879del	chr12:49436102	4.80%	5.19%	N/A	7.69%
ASXL1	G645Vfs*58	c.1926del	chr20:32434639	21.95%	N/A	N/A	N/A
ASXL1	G646Wfs*12	c.1934dup	chr20:31022441	8.84%	22.80%	8.60%	N/A
c-MYC	AMP	AMP		3.33	N/A	N/A	N/A
RAC1	N92I	c.275A>T	chr7:6439806	13.67%	14.26%	18.09%	14.81%
ACVR2A	K437Rfs*5	c.1310delA	chr2:148683686	62.45%	N/A	N/A	N/A

Product Information&emsp;
Intended Use	Research Use Only
Unit Size	1ug/vial * 1 vial
Concentration	Download for COA
Purity	Download for COA
DNA electrophoresis	Download for COA
Storage	4°C
Expiry	36 months from the date of manufacture

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Panel-Ref® gDNA All-in-One Reference Standard Plus

Detailed introduction

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