MDM2 Loss Reference Standard | |
| Format | Genomic DNA |
| Description | MDM2, MDM2 proto-oncogene, is an E3 ubiquitin protein ligase that mediates Tp53 degradation and therefore, regulates apoptosis and cell-cycle (PMID: 27993876). Amplification and/or overexpression of MDM2 has been identified in several cancer types (PMID: 23303139, PMID: 31440117) and amplification is common in liposarcoma (PMID: 30237864) and has been observed with Mdm2 overexpression in anaplastic lymphoma kinase (ALK)-negative inflammatory myofibroblastic tumors (PMID: 32195970). |
| Technical Data | |
| Copy number | 1 |
| Definition | Loss |
| Product Information | |
| Intended Use | Research Use Only |
| Unit Size | 1ug |
| Concentration | Download for COA |
| Purity | Download for COA |
| DNA electrophoresis | Download for COA |
| Sanger sequencing | Download for COA |
| Storage | 4℃ |
| Expiry | 36 months from the date of manufacture |
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